ErbB 3 is an active tyrosine kinase capable of homo - and hetero - interactions 2 3
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چکیده
1 ErbB3 is an active tyrosine kinase capable of homoand hetero-interactions 2 3 Mara P. Steinkamp a,c , Shalini T. Low-Nam a *, Shujie Yang a▲ , 4 Keith A. Lidke b,c , Diane S. Lidke a,c and Bridget S. Wilson a,c# 5 6 Department of Pathology a , Department of Physics b and Cancer Center c 7 University of New Mexico, Albuquerque, New Mexico 87131 8 9 10 11 12 13 Running Head: erbB3 participates in homoand hetero-interactions 14 15 16 *Current address: Shalini Low-Nam, South Dakota State University, Brooking, SD 57007 17 ▲ Current address: Shujie Yang, University of Iowa, Iowa City, IA, 52242 18 19 20
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A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.
The ErbB family includes four homologous transmembrane tyrosine kinases. Whereas ErbB-1 binds to the epidermal growth factor (EGF), both ErbB-3 and ErbB-4 bind to the Neu differentiation factors (NDFs, or neuregulins), and ErbB-2, the most oncogenic family member, is an orphan receptor whose function is still unknown. Because previous lines of evidence indicated the existence of interreceptor i...
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